Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas (TCGA)

The renal cell carcinomas, clear cell, papillary, and chromophobe, have recently undergone an unmatched genomic characterization by The Cancer Genome Atlas (TCGA). This analysis has revealed new insights into each of these malignancies, and underscores the unique biology of clear cell, papillary, and chromophobe renal cell carcinoma. Themes that have emerged include distinct mechanisms of metabolic dysregulation and common mutations in chromatin modifier genes. Importantly, the papillary renal cell carcinoma classification encompasses a heterogeneous group of diseases, each with highly distinct genetic and molecular features. In conclusion, this review summarizes renal cell carcinomas which represent a diverse set of malignancies, each with novel biological programs that define new paradigms for cancer biology. on October 19, 2017. © 2016 American Association for Cancer Research. mcr.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on June 21, 2016; DOI: 10.1158/1541-7786.MCR-16-0115